Key result
Genome-wide linkage analysis strongly links regions 2p14 and 3p14.1 to hypertension and blood pressure.
Why the study?
Does genome-wide linkage analysis identify susceptibility variants for hypertension and blood pressure in the FBPP dataset?
Meta-Analysis (n=12,028)
Yes
Does genome-wide linkage analysis identify susceptibility variants for hypertension and blood pressure in the FBPP dataset?
An updated meta-analysis of over 12,000 individuals identified regions 2p14 and 3p14.1 as strong candidate locations for hypertension susceptibility variants.
A meta-analysis of the results from a multicenter genome-wide linkage study for hypertension and blood pressure (BP) based on an initial sample of 6,245 individuals was published in 2003. We report here a combined linkage analysis of hypertension and BP using the complete Family Blood Pressure Program (FBPP) dataset, which includes a total of 12,028 genotyped individuals. Genome-wide linkage analyses for hypertension and BP were first performed in each of the studied ethnic group within each network and the results were combined with a meta-analysis using a modified Fisher's method of combining P values. Our meta-analysis of genome scans for the latest FBPP dataset reveals suggestive linkage for hypertension and BP at several regions on the human genome. Strong evidence for linkage at two of these regions, 2p14 and 3p14.1, have also been published in previous meta-analyses, making them good candidate locations for susceptibility variants.
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Wu et al. (2006) conducted a meta-analysis in Hypertension and blood pressure (n=12,028). Genome-wide linkage analysis was evaluated on Linkage for hypertension and blood pressure. A meta-analysis of genome scans in 12,028 individuals revealed strong evidence for linkage for hypertension and blood pressure at regions 2p14 and 3p14.1.
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