Key result
Genome-wide linkage scans find no genomic regions with uniformly large effects on BP across populations.
Population
6,245 relatives from multiple ethnic groups across four multicenter networks in the National Heart, Lung and…
Design
Meta-analysis
Authors
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No large-effect loci support simple genetic screening for hypertension risk; confirms polygenic architecture and shifts research to association studies.
Meta-Analysis (n=6,245)
Yes
Effect estimate: LOD < 2
A meta-analysis of genome-wide linkage scans found no single genetic region with uniformly large effects on blood pressure or hypertension across diverse populations.
Michael A. Province (2003) conducted a meta-analysis in Hypertension (n=6,245). Genome-wide linkage scans was evaluated on Genetic linkage to hypertension/blood pressure (LOD score) (LOD < 2). A meta-analysis of genome-wide linkage scans found no genomic regions with uniformly large effects on blood pressure or hypertension across all populations, with no region reaching a LOD >2.
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