Key result
Genome-wide linkage and association studies are revealing novel variants, epistatic interactions, and sexually dimorphic loci that contribute to the genetic architecture of hypertension.
Genome-wide linkage and association studies are revealing novel genetic architectures, including epistatic and sexually dimorphic loci, that contribute to blood pressure variation.
Novel loci refine hypertension genetic architecture; leaves open clinical translation to risk prediction or therapy.
PURPOSE OF REVIEW: The current review focuses on new trends in genome-wide assessment of the inherited component of blood pressure variation. RECENT FINDINGS: Systematic linkage and association analyses of a region on chromosome 1q, complemented by gene prioritization with comparative genomic evidence, revealed variants in three genes contributing to tangible increases in blood pressure. The results of one of the first two-dimensional scans were published, confirming the oligogenic epistatic nature of the genetic component of blood pressure determination. Several loci with distinct effects on blood pressure in men and women were reported, enhancing the sexually dimorphic map of complex traits. Novel approaches were applied to extract genetically and clinically distinct subsets of garden-variety hypertension, which appears to be a promising direction to take in deciphering the hypertension genetic puzzle. SUMMARY: The current landscape of genome-wide linkage studies of hypertension is acquiring novel facets in an attempt to more appropriately grasp the genomic architecture of hypertension. The advent of genome-wide association investigations, enhanced possibilities of comparative genomics and integration with information on copy number variations and transcriptomics will most likely reshape our view of nature and the evolutionary connotations of genetic variation affecting blood pressure in the near future.
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Hamet et al. (2007) conducted a review in hypertension. genome-wide scanning was evaluated. Genome-wide linkage and association studies are revealing novel variants, epistatic interactions, and sexually dimorphic loci that contribute to the genetic architecture of hypertension.
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