Identification of novel genes associated with blood pressure regulation may lead to an improved understanding of hypertension and the potential for novel therapies.
These associations do not yet guide hypertension care; leaves open functional validation and therapeutic translation.
PURPOSE OF REVIEW: Hypertension is a complex trait with multiple environmental and genetic contributors. Until recently, linkage studies of rare Mendelian disorders of hypertension and hypotension have produced the most notable progress toward understanding the heritable basis of blood pressure (BP). Association studies to identify common variants have been limited in the past by small sample sizes and most findings have lacked replication. RECENT FINDINGS: Recently, well powered, targeted candidate gene and genome-wide association studies have reported reproducible associations between rare and common genetic variants and BP and hypertension at the population level. SUMMARY: Identification of novel genes will lead to an improved understanding of BP regulation and the potential for novel therapies.
No takes yet. Share an insight, caveat, or question.
Arora et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: