What is the clinical evidence from this study?

Study design: Other. Population: Pestivirus infection. Intervention: Monoclonal antibodies against NADL strain of BVDV. Primary outcome: Reactivity with Pestivirus isolates by indirect immunofluorescent assay.

What does this research mean for the field?

Monoclonal antibody 4G8 reacts specifically with all tested bovine viral diarrhoea virus (BVDV) isolates without cross-reacting with hog cholera virus or border disease virus, providing a means for differential pestivirus diagnosis. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 12, 1988Journal of Veterinary Medicine Series B

Production of Monoclonal Antibodies to Bovine Virus Diarrhoea Virus and their Reactivity with Selected Pestivirus Isolates

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Key result

Monoclonal antibody 4G8 specifically reacts with 26 BVDV isolates, showing potential utility for differential Pestivirus diagnosis.

Population

26 isolates of Bovine Virus Diarrhoea Virus, 5 isolates of Hog Cholera Virus, and 4 isolates of Border…

Design

Preclinical

Authors

PMP. H. McHugh DMD.P. MackieQueen's University Belfast MMM. S. McNultyQueen's University Belfast

Discussion

Member takes

Implication

May aid BVDV differential diagnosis in veterinary settings; leaves open prospective validation in clinical samples.

Structured PICO

Population

26 isolates of Bovine Virus Diarrhoea Virus (BVDV), 5 isolates of Hog Cholera Virus (HCV), and 4 isolates of Border Disease Virus (BDV)

Intervention

Three monoclonal antibodies against the NADL strain of BVDV (4G8, 4F4, 4H12)

Outcome

Reactivity by indirect immunofluorescent assaysurrogate

Monoclonal antibody 4G8 specifically recognizes BVDV isolates without cross-reacting with HCV or BDV, suggesting utility in the differential diagnosis of Pestivirus infections.

Cite This Study

McHugh et al. (1988) studied Pestivirus infection. Monoclonal antibodies against NADL strain of BVDV was evaluated on Reactivity with Pestivirus isolates by indirect immunofluorescent assay. Monoclonal antibody 4G8 reacted with all 26 BVDV isolates but none of the HCV or BDV isolates, indicating potential utility in the differential diagnosis of Pestivirus infection.

synapsesocial.com/papers/6aa691f1041e43fea73a7b8b https://doi.org/10.1111/j.1439-0450.1988.tb00489.x

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January 12, 1988Journal of Veterinary Medicine Series B

Production of Monoclonal Antibodies to Bovine Virus Diarrhoea Virus and their Reactivity with Selected Pestivirus Isolates

View Full Paper

Ask AI

Bookmark

Key result

Monoclonal antibody 4G8 specifically reacts with 26 BVDV isolates, showing potential utility for differential Pestivirus diagnosis.

Population

26 isolates of Bovine Virus Diarrhoea Virus, 5 isolates of Hog Cholera Virus, and 4 isolates of Border…

Design

Preclinical

Authors

PMP. H. McHugh DMD.P. MackieQueen's University Belfast MMM. S. McNultyQueen's University Belfast

Discussion

Member takes

Implication

May aid BVDV differential diagnosis in veterinary settings; leaves open prospective validation in clinical samples.

Structured PICO

Population

26 isolates of Bovine Virus Diarrhoea Virus (BVDV), 5 isolates of Hog Cholera Virus (HCV), and 4 isolates of Border Disease Virus (BDV)

Intervention

Three monoclonal antibodies against the NADL strain of BVDV (4G8, 4F4, 4H12)

Outcome

Reactivity by indirect immunofluorescent assaysurrogate

Monoclonal antibody 4G8 specifically recognizes BVDV isolates without cross-reacting with HCV or BDV, suggesting utility in the differential diagnosis of Pestivirus infections.

Cite This Study

synapsesocial.com/papers/6aa691f1041e43fea73a7b8b https://doi.org/10.1111/j.1439-0450.1988.tb00489.x

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

1Border disease without nervous signs or fleece changes1987 · 34 citations

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