Key result
HOE 498 safely reduces blood pressure up to a 10-mg dose before causing symptomatic orthostatic hypotension.
Why the study?
Does HOE 498 reduce blood pressure in patients with mild essential hypertension compared to placebo?
RCT
Does HOE 498 reduce blood pressure in patients with mild essential hypertension compared to placebo?
HOE 498 is a long-acting ACE inhibitor that effectively reduces blood pressure at 5 to 10 mg doses, but causes symptomatic orthostatic hypotension at 20 mg.
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5-10 mg doses merit further study in hypertension; leaves open safety and efficacy versus placebo in controlled trials.
Leeuw et al. (1985) conducted an RCT in mild essential hypertension. HOE 498 vs. placebo was evaluated on blood pressure and converting enzyme levels. Single doses of 5 or 10 mg of HOE 498 reduced blood pressure, with complete converting enzyme inhibition at 10 mg, whereas a 20-mg dose caused symptomatic orthostatic hypotension.
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