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February 1, 1978The Journal of Clinical Endocrinology & Metabolism

Effect of Angiotensin Converting Enzyme Inhibition on Blood Pressure, Plasma Renin Activity and Plasma Aldosterone in Essential Hypertension *

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Why the study?

Does an angiotensin converting enzyme inhibitor alter blood pressure, plasma renin activity, and plasma aldosterone in patients with essential hypertension under varying sodium and postural states?

Population

15 patients with essential hypertension

Design

Case_series

Authors

HGHaralambos GavrasGeneral / Preventive / LipidsSTStephen C. TextorVascular MedicineLVLadislav VolicerUniversity of South Florida

Discussion

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Implication

Postural aldosterone escape despite ACE inhibition in one case; leaves open non-angiotensin II regulators in essential hypertension.

Structured PICO

Does an angiotensin converting enzyme inhibitor alter blood pressure, plasma renin activity, and plasma aldosterone in patients with essential hypertension under varying sodium and postural states?

P
Population
15 patients with essential hypertension
I
Intervention
Angiotensin converting enzyme inhibitor administered via injection after periods of sodium depletion and repletion
O
Outcome
Responses of blood pressure, plasma renin activity, and plasma aldosterone in the supine and erect positionsurrogate

Postural increases in blood pressure and plasma aldosterone despite ACE inhibition suggest that factors other than angiotensin II participate in regulating these parameters in essential hypertension.

Cite This Study

Gavras et al. (1978) studied this question.

synapsesocial.com/papers/6a840e9a22fbfbf8d78d68cbhttps://doi.org/10.1210/jcem-46-2-220

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Angiotensin Converting-Enzyme Inhibitor to Identify and Treat Vasoconstrictor and Volume Factors in Hypertensive Patients1974 · 355 citations
  2. 2Treatment of Patients with Severe Hypertension by Inhibition of Angiotensin-Converting Enzyme1974 · 24 citations
  3. 3Effects of Sodium Loading, Sodium Depletion and Posture on Plasma Aldosterone Concentration and Renin Activity in Hypertensive Patients1969 · 70 citations
  4. 4Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats1973 · 291 citations
  5. 5Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.1976 · 164 citations