Key result
High pulse pressure and mean blood pressure are linked to ~5-fold higher odds of IGT.
Cross-Sectional (n=695)
No
In middle-aged subjects not taking antihypertensive medications, both elevated pulse pressure and elevated mean blood pressure are independently associated with impaired glucose tolerance.
May prompt glucose tolerance screening in middle-aged adults with elevated pulse or mean pressure; leaves open causality and requires prospective confirmation.
In a study of 695 middle-aged subjects, without antihypertensive agents, and without more pronounced obesity, both pulse pressure (PP) and mean blood pressure (MBP) were strongly related to 2-h blood glucose in 75 g OGTTs (p < 0.001). All hypertensives (DBP > or = 90 mm Hg) were separated into 39 with higher PP (> or = 60 mm Hg) and 137 with lower PP (< 60 mm Hg). The high PP hypertensives, compared with the low PP hypertensives and all 519 normotensives, had higher frequency of impaired glucose tolerance (IGT; WHO-criteria), 33%, 6%, and 4%, respectively (p < 0.001), and also higher mean 2-h blood glucose, 5.9, 4.5, and 4.2 mmol.l-1, respectively (p < 0.001). These differences were independent of MBP levels. Similarly, all 54 hypertensives with higher MBP (> or = 110 mm Hg) had more IGT and higher 2-h glucose than the 122 hypertensives with lower MBP (< 110 mm Hg) or the normotensives, 30%, 5% and 4%, respectively (p < 0.001), and 5.8, 4.4, 4.2 mmol.l-1, respectively (p < 0.001), independently of PP. Thus, both high PP and high MBP were related to IGT, independently of each other.
No takes yet. Share an insight, caveat, or question.
Cederholm et al. (1992) conducted a cross-sectional in Impaired Glucose Tolerance and Hypertension (n=695). High pulse pressure (PP ≥60 mm Hg) vs. Low pulse pressure (PP <60 mm Hg) and normotension was evaluated on Impaired glucose tolerance (IGT) (OR 5.2, 95% CI 2.2-12.5, p=<0.001). High pulse pressure and high mean blood pressure were independently associated with a significantly increased prevalence of impaired glucose tolerance (OR 5.2) in middle-aged subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: