Treatment of tosyl-l-homoserine lactone (I) with hydrogen bromide, followed by recyclization by the use of sodium hydride below 20°C, gave tosyl-l-azetidine-2-carboxylic acid (III). After the detosylation, the optically active azetidine-2-carboxylic acid (IV) was obtained in a good yield.
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Miyoshi et al. (1973) studied this question.
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