Key result
Right nucleus ambiguus stimulation predominantly slows atrial rate while left stimulation slows ventricular rate.
Population
Open-chest male mongrel dogs anesthetized with thiopental sodium and respired
Design
Preclinical
Follow-up
Acute
Authors
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May inform side-specific vagal neuromodulation for rate control; leaves open human translation from this animal model.
This preclinical study demonstrates differential vagal control of the heart, with the right nucleus ambiguus predominantly controlling atrial rate and the left predominantly controlling ventricular rate.
Thompson et al. (1987) studied this question. Stimulation of the nucleus ambiguus was evaluated on Atrial and ventricular rates. Stimulation of the right nucleus ambiguus predominantly slowed the atrial rate, whereas left-side stimulation predominantly slowed the ventricular rate.
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