Key result
LMWH prophylaxis progressively loses effect on thrombin generation as pregnancy advances in women with thrombophilia.
Why the study?
Does low-molecular-weight heparin prophylaxis effectively reduce thrombin generation throughout pregnancy in women with thrombophilia?
Population
70 pregnant women with severe (n=8), mild (n=47), and no (n=15) thrombophilia
Comparison
Low-molecular-weight heparin (LMWH) prophylaxis vs Non-pregnant state and pre-administration baseline
Design
Cohort
Follow-up
Throughout pregnancy up to 8 weeks postpartum
Authors
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LMWH effect on thrombin generation wanes in late pregnancy; leaves open whether dose adjustment improves VTE prevention in thrombophilic women.
Cohort (n=70)
Does low-molecular-weight heparin prophylaxis effectively reduce thrombin generation throughout pregnancy in women with thrombophilia?
The efficacy of LMWH prophylaxis in suppressing thrombin generation decreases as pregnancy progresses in women with thrombophilia, suggesting a potential need for dose adjustments.
Selmeczi et al. (2014) conducted a cohort in Thrombophilia in pregnancy (n=70). Low-molecular-weight heparin (LMWH) prophylaxis vs. Baseline / non-pregnant state was evaluated on Thrombin generation (peak thrombin and endogenous thrombin potential). Low-molecular-weight heparin (LMWH) prophylaxis showed a progressively decreasing effect on thrombin generation with advancing stages of pregnancy in women with thrombophilia.
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