Key result
Fontan fenestration closure is linked to ~9% higher O2 saturation and less anticongestive medication use.
Why the study?
Does catheter closure of Fontan fenestration improve oxygenation and clinical outcomes in Fontan patients?
Population
154 patients who underwent catheter closure of a Fontan fenestration without additional significant leaks
Comparison
Catheter closure of Fontan fenestration vs Baseline (pre-closure)
Design
Cohort
Follow-up
median 3.4 years
Authors
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Fenestration closure was associated with improved oxygenation and fewer medications in Fontan patients; hypothesis-generating and requires randomized confirmation.
Cohort (n=154)
Does catheter closure of Fontan fenestration improve oxygenation and clinical outcomes in Fontan patients?
Catheter closure of Fontan fenestrations is associated with improved oxygenation, reduced need for heart failure medications, and improved somatic growth, with rare chronic decompensation.
Goff et al. (2000) conducted a cohort in Fontan physiology with fenestration (n=154). Catheter closure of Fontan fenestration vs. Baseline (pre-closure) was evaluated on Clinical decompensation. Catheter closure of Fontan fenestrations increased O2 saturation by 9.4% (P<0.001) and reduced anticongestive medication use, with rare clinical decompensation (4.5%) over a median 3.4 years.
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