Key result
Grade 3 or higher pulmonary regurgitation post-ToF repair is linked to right ventricular hypertension.
Why the study?
How does the degree of postoperative pulmonary regurgitation and pulmonary stenosis affect late hemodynamics and cardiac function in patients following complete repair of tetralogy of Fallot?
Cohort (n=63)
How does the degree of postoperative pulmonary regurgitation and pulmonary stenosis affect late hemodynamics and cardiac function in patients following complete repair of tetralogy of Fallot?
Following complete repair of tetralogy of Fallot, limiting pulmonary regurgitation to grade 2 or less is critical for maintaining excellent long-term postoperative hemodynamics and cardiac function.
May support limiting PR to grade ≤2 after tetralogy of Fallot repair to preserve RV function; hypothesis-generating in Level 3 cohort data.
Late results were studied in 63 patients who underwent complete repair of tetralogy of Fallot. Mild pulmonary stenosis (PS) was present in 73%, moderate PS in 17% and severe PS in 10% of the patients. When a transannular patch was used, wider enlargement of the pulmonary annulus did not always relate to a decrease in right ventricular pressure and right ventricular to pulmonary artery pressure gradient in the late postoperative period. Pulmonary regurgitation (PR) of grade 2 or less did not relate to the late postoperative hemodynamics and cardiac function. PR of grade 3 or over led to right ventricular and pulmonary artery hypertension, and to increases in right ventricular end-diastolic volume and CTR. PR of grade 4 impaired left ventricular function. PR of grade 3 or over with moderate PS led to elevation in right ventricular end-diastolic pressure. In patients with mild PS and PR of grade 2 or less, late postoperative hemodynamics and cardiac function were excellent. To maintain excellent postoperative hemodynamics and cardiac function, it is imperative to obtain PR of grade 2 or less and to use a procedure which will lead to excellent development of the pulmonary annulus. In conventional procedures using a transannular patch, a CSAI of less than 2.5 cm2/m2 and precise coaptation between the original pulmonary cusp and the cusp mounted on the patch will aid in avoiding significant PR.
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Oku et al. (1986) conducted a cohort in Tetralogy of Fallot (n=63). Complete repair of tetralogy of Fallot was evaluated on Late postoperative hemodynamics and cardiac function. Following complete repair of tetralogy of Fallot, pulmonary regurgitation of grade 3 or higher led to right ventricular hypertension, whereas grade 2 or less maintained excellent cardiac function.
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