Key result
Therapeutic paroxetine lacks significant hemodynamic or electrophysiological effects in depressed patients and healthy men.
Why the study?
Does paroxetine have lower cardiovascular toxicity compared to tricyclic antidepressants in depressive patients and healthy men?
Population
Depressive patients and healthy men
Comparison
Paroxetine vs Classical tricyclic antidepressants
Design
Review
Authors
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Supports paroxetine's cardiovascular safety versus tricyclics in reviewed data; leaves open randomized confirmation before practice change.
Does paroxetine have lower cardiovascular toxicity compared to tricyclic antidepressants in depressive patients and healthy men?
Paroxetine appears to have a safer cardiovascular profile compared to classical tricyclic antidepressants, lacking significant haemodynamic or electrophysiological effects.
Warrington et al. (1992) conducted a review in Depression. Paroxetine vs. Tricyclic antidepressants was evaluated on Haemodynamic or electrophysiological effects. Therapeutic doses of paroxetine lack any important haemodynamic or electrophysiological effects in depressive patients and healthy men.
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