What does this research mean for the field?

Idiopathic dilated cardiomyopathy is associated with elevated levels of circulating activated HLA-DR-expressing T helper and cytotoxic lymphocytes compared to ischemic heart failure and healthy controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 12, 2008Cardiology

Increased Level of HLA-DR-Expressing T Lymphocytes in Peripheral Blood from Patients with Idiopathic Dilated Cardiomyopathy

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Idiopathic dilated cardiomyopathy (n=39). Intervention: Idiopathic dilated cardiomyopathy vs. Ischemic congestive heart failure and controls. Primary outcome: Levels of HLA-DR-positive T helper/inducer cells.

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Key result

Idiopathic DCM linked to elevated HLA-DR-positive T helper cells at 2.8% versus ischemic heart failure.

n=39

Population

14 patients with idiopathic dilated cardiomyopathy, 13 patients with ischemic congestive heart failure, and…

Design

Case-control

Authors

LNL.E. R ouml nnblom HFHåkan ForsbergSunderby sjukhus PEPer‐Eric EvrinUppsala University

Discussion

Member takes

Implication

Does not support lymphocyte profiling to differentiate cardiomyopathies; leaves open broader immune characterization in IDC.

Study Design

Type

Observational (n=39)

Structured PICO

Population

39 participants comprising 14 patients with idiopathic dilated cardiomyopathy, 13 with ischemic congestive heart failure, and 12 controls.

Comparator

Patients with ischemic congestive heart failure and healthy controls

Outcome

Levels of HLA-DR-expressing T helper/inducer (Leu-3a) and T cytotoxic/suppressor cells (Leu-2a) in peripheral bloodsurrogate

Main Result

Absolute Event Rate: 2.8% vs 0.6%

Patients with idiopathic dilated cardiomyopathy exhibit increased levels of activated T lymphocytes, suggesting an immune-mediated component in its pathogenesis.

Cite This Study

nnblom et al. (2008) conducted an observational in Idiopathic dilated cardiomyopathy (n=39). Idiopathic dilated cardiomyopathy vs. Ischemic congestive heart failure and controls was evaluated on Levels of HLA-DR-positive T helper/inducer cells. Idiopathic dilated cardiomyopathy was associated with increased levels of HLA-DR-positive T helper/inducer cells (2.8%) compared to ischemic congestive heart failure (0.8%) and controls (0.6%).

synapsesocial.com/papers/6aa6a2efd7cdd2657b78e5eb https://doi.org/10.1159/000174781

Topics

Heart failure HFrEF treatment

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Increased Level of HLA-DR-Expressing T Lymphocytes in Peripheral Blood from Patients with Idiopathic Dilated Cardiomyopathy

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Increased Level of HLA-DR-Expressing T Lymphocytes in Peripheral Blood from Patients with Idiopathic Dilated Cardiomyopathy

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

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Topics

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