Key result
Cardiac glycoside efficacy and indications for heart failure vary historically between the UK and US.
Provides a historical perspective on the controversy surrounding the efficacy and indications of digoxin in heart failure.
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Historical UK-US divergence on digoxin for HF warrants cautious prescribing today; leaves open need for updated efficacy trials.
Thomas W. Smith (1993) conducted a review in Heart failure. Cardiac glycosides (Digoxin) was evaluated. Historical perspectives on the efficacy and indications of cardiac glycosides for heart failure have varied significantly between the United Kingdom and the United States.
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