What question did this study set out to answer?

To assess the utility of radioimmunoassay and enzyme-linked immunosorbent assay in measuring immunoglobulin G antibody response to purified protein derivative for tuberculosis diagnosis.

January 1, 1982Journal of Clinical MicrobiologyOpen Access

Detection of immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay

View Full Paper

Ask AI

Bookmark

Authors

CZC. Raymond ZeissNorthwestern University RRRobert C. RadinNorthwestern University JWJ. E. WilliamsDurham University

Discussion

Member takes

Implication

Comparative assay evaluation demonstrates elevated immunoglobulin G against purified protein derivative in active tuberculosis, suggesting strong potential for rapid diagnostic testing.

Key Points

To assess the utility of radioimmunoassay and enzyme-linked immunosorbent assay in measuring immunoglobulin G antibody response to purified protein derivative for tuberculosis diagnosis.
Assayed serum samples from patients with active tuberculosis and control individuals using a polystyrene tube radioimmunoassay and an enzyme-linked immunosorbent assay.
Quantified immunoglobulin G antibody reactivity against purified protein derivative antigen within a 24-hour testing window.
Both immunoassays showed a marked increase in immunoglobulin G antibody activity among patients with active tuberculosis.
No overlap in antibody levels occurred between the active tuberculosis patient group and purified protein derivative skin test-positive control individuals.
Both assays achieved high replication accuracy and yielded quantitative antibody measurements within 24 hours.

Cite This Study

Zeiss et al. (1982) studied this question.

synapsesocial.com/papers/6aa6a8de3f91f0dc527916d7 https://doi.org/10.1128/jcm.15.1.93-96.1982

View Full Paper

Ask AI

Bookmark

Implication

Comparative assay evaluation demonstrates elevated immunoglobulin G against purified protein derivative in active tuberculosis, suggesting strong potential for rapid diagnostic testing.

Detection of immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay

Discussion

Member takes

Implication

Key Points

Cite This Study

Detection of immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider