What question did this study set out to answer?

To determine whether an enzyme-linked immunosorbent assay measuring IgG antibody activity against purified protein derivative can differentiate active pulmonary tuberculosis from other mimicking pulmonary diseases and controls.

March 1, 1983The Journal of Infectious Diseases

Use of an Enzyme-Linked Immunosorbent Assay Technique in the Differential Diagnosis of Active Pulmonary Tuberculosis in Humans

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Authors

SKSteve B. KalishNorthShore University HealthSystem RRRobert C. RadinNorthwestern University JPJohn PhairIcahn School of Medicine at Mount Sinai

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Implication

Diagnostic study reveals elevated IgG against purified protein derivative in active pulmonary tuberculosis compared to mimicking diseases, suggesting utility as a rapid diagnostic aid.

Key Points

To determine whether an enzyme-linked immunosorbent assay measuring IgG antibody activity against purified protein derivative can differentiate active pulmonary tuberculosis from other mimicking pulmonary diseases and controls.
Assayed serum samples for immunoglobulin G (IgG) antibody activity against purified protein derivative (PPD) using an enzyme-linked immunosorbent assay (ELISA).
Developed a standardization protocol to limit assay variability across patients with active pulmonary tuberculosis, mimicking pulmonary disorders, vaccinated cohorts, and controls.
Patients with active pulmonary tuberculosis had significantly higher mean antibody levels than patients with atypical tuberculosis (P = 0.005), sarcoidosis (P = 0.0001), histoplasmosis (P = 0.004), blastomycosis (P = 0.008), or cryptococcosis (P = 0.017).
Active tuberculosis antibody levels were also significantly greater than those in BCG-vaccinated individuals (P = 0.003), patients with treated tuberculosis (P = 0.003), and PPD skin test-positive or skin test-negative controls (P = 0.001).

Cite This Study

Kalish et al. (1983) studied this question.

synapsesocial.com/papers/6a8737a324dcec08efbf0e52 https://doi.org/10.1093/infdis/147.3.523

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Implication

Diagnostic study reveals elevated IgG against purified protein derivative in active pulmonary tuberculosis compared to mimicking diseases, suggesting utility as a rapid diagnostic aid.

Use of an Enzyme-Linked Immunosorbent Assay Technique in the Differential Diagnosis of Active Pulmonary Tuberculosis in Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

Use of an Enzyme-Linked Immunosorbent Assay Technique in the Differential Diagnosis of Active Pulmonary Tuberculosis in Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

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