Key result
HPeV linked to acute CNS infections in the first reported Indian adult and pediatric cases.
Why the study?
Human parechovirus can cause severe central nervous system infections across age groups, but cases had not been previously reported from India.
Case Report (n=2)
This report documents the first cases of acute Human Parechovirus CNS infections in India, highlighting its potential to cause severe neurological disease in both adults and children.
Clinicians should consider HPeV in unexplained CNS infections across ages; leaves open true incidence in India pending systematic testing.
The manifestations of HPeV infection vary from asymptomatic to serious conditions like meningitis, encephalitis, and neonatal sepsis.[1,2] While the infection is common among children, especially newborns, recent studies have demonstrated that HPeV can lead to severe cases of meningitis and encephalitis in adults.[3] We present the first cases of acute HPeV CNS infections from India, meningitis in an adult and meningoencephalitis in a paediatric patient.
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Panmei et al. (2025) conducted a case report in Human Parechovirus (HPeV) CNS infections (n=2). Human Parechovirus (HPeV) infection was evaluated on Clinical presentation of HPeV CNS infection. Human Parechovirus (HPeV) infection caused acute CNS infections, presenting as meningitis in an adult and meningoencephalitis in a pediatric patient, representing the first such cases from India.
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