Key result
Human parechovirus 3 infection in two premature infants was associated with severe periventricular leukomalacia and viral localization in meninges and vascular smooth muscle.
Case Report (n=2)
HPeV3-associated leukoencephalopathy in infants may be driven by infection of meningeal blood vessels and subsequent vascular compromise rather than direct brain tissue infection.
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Suggests vascular pathogenesis in HPeV3 leukoencephalopathy; hypothesis-generating and requires confirmation before clinical implications.
Bissel et al. (2015) conducted a case report in Human parechovirus 3 (HPeV3) infection (n=2). Human parechovirus 3 (HPeV3) infection was evaluated on Pathologic findings. Human parechovirus 3 infection in two premature infants was associated with severe periventricular leukomalacia and viral localization in meninges and vascular smooth muscle.
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