Key result
Two neonates with human parechovirus type 3 encephalitis presented with fever, irritability, and seizures, showing white matter damage on MRI despite normal cerebrospinal fluid analyses.
Case Report (n=2)
Human parechovirus type 3 can cause neonatal encephalitis presenting with fever, irritability, seizures, and white matter damage on MRI.
Raises awareness of parechovirus encephalitis in neonates despite normal CSF; hypothesis-generating for diagnostic strategies and outcomes research.
We report 2 neonates with human parechoviruses type 3 encephalitis. Both newborns presented with fever, irritability and seizures. Cerebrospinal fluid analyses were normal, but magnetic resonance imaging revealed white matter damage, suggesting human parechoviruse infection. Human parechoviruses type 3-RNA was detected in cerebrospinal fluid samples and in blood, stool, urine and respiratory samples, indicating the dissemination of the virus.
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Pariani et al. (2014) conducted a case report in Human parechovirus type 3 encephalitis (n=2). Human parechovirus type 3 infection was evaluated on Clinical presentation and diagnostic findings. Two neonates with human parechovirus type 3 encephalitis presented with fever, irritability, and seizures, showing white matter damage on MRI despite normal cerebrospinal fluid analyses.
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