Key result
Presumed intrauterine HPeV-3 infection is linked to neonatal meningoencephalitis and severe developmental delay.
Why the study?
Parechovirus type 3 infection is an important cause of illness in neonates, but cases with presumed intrauterine onset and associated neurodevelopmental outcomes are not described.
Intrauterine onset of HPeV-3 infection should be considered in cases of inexplicable neonatal meningoencephalitis.
Consider intrauterine HPeV-3 in unexplained neonatal meningoencephalitis; hypothesis-generating and requires prospective confirmation.
Parechovirus type 3 (HPeV-3) infection is an important cause of illness in neonates. We present the first case of an infant with a HPeV-3 meningoencephalitis which presumably commenced in utero. Severe developmental delay was seen. In the case of inexplicable neonatal meningoencephalitis, an intrauterine onset of HPeV-3 infection might be the cause.
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Salavati et al. (2020) studied this question. Presumed intrauterine Parechovirus type 3 (HPeV-3) infection can cause neonatal meningoencephalitis resulting in severe developmental delay.
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