Key result
Diabetes linked to ~37% higher hospitalization rates and greater burden in stable HFrEF.
Why the study?
Diabetes mellitus is associated with increased risk of hospitalisation in people with HFrEF, but little is known about the causes of these events.
Does diabetes mellitus increase the rate and burden of hospitalisation in people with stable HFrEF?
Cohort (n=711)
Does diabetes mellitus increase the rate and burden of hospitalisation in people with stable HFrEF?
Absolute Event Rate: 1.07% vs 0.78%
p-value: p=<0.001
In patients with stable HFrEF, comorbid diabetes mellitus significantly increases the rate and burden of hospitalizations, particularly due to decompensated heart failure, other cardiovascular events, and infections.
May support closer surveillance in stable HFrEF with diabetes; leaves open whether interventions modify hospitalization risk.
Introduction Diabetes mellitus (DM) is associated with increased risk of hospitalisation in people with heart failure and reduced ejection fraction (HFrEF). However, little is known about the causes of these events. Methods Prospective cohort study of 711 people with stable HFrEF. Hospitalisations were categorised by cause as: decompensated heart failure; other cardiovascular; infection or other non-cardiovascular. Rates of hospitalisation and burden of hospitalisation (percentage of follow-up time in hospital) were compared in people with and without DM. Results After a mean follow-up of 4.0 years, 1568 hospitalisations occurred in the entire cohort. DM (present in 32% [ n=224]) was associated with a higher rate (mean 1.07 vs 0.78 per 100 patient-years; p<0.001) and burden (3.4 vs 2.2% of follow-up time; p<0.001) of hospitalisation. Cause-specific analyses revealed increased rate and burden of hospitalisation due to decompensated heart failure, other cardiovascular causes and infection in people with DM, whereas other non-cardiovascular causes were comparable. Infection made the largest contribution to the burden of hospitalisation in people with and without DM. Conclusions In people with HFrEF, DM is associated with a greater burden of hospitalisation due to decompensated heart failure, other cardiovascular events and infection, with infection making the largest contribution.
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Malik et al. (2022) conducted a cohort in stable HFrEF (n=711). Diabetes mellitus vs. Without diabetes mellitus was evaluated on Rate of hospitalisation (per 100 patient-years) (p=<0.001). Diabetes mellitus was associated with a higher rate of hospitalisation (1.07 vs 0.78 per 100 patient-years; p<0.001) and greater hospitalisation burden in patients with stable HFrEF.
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