Key result
Beta-blockers reduce plasma renin activity during upright exercise independent of receptor selectivity.
Why the study?
Do various beta-adrenergic blocking agents reduce plasma renin activity at rest and during exercise in normal volunteers?
Population
8 normal volunteers
Design
Other
Authors
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Beta-blockers may lower BP partly via exercise renin suppression; hypothesis-generating for selectivity-independent effects in hypertension.
Do various beta-adrenergic blocking agents reduce plasma renin activity at rest and during exercise in normal volunteers?
Various beta-blockers suppress plasma renin activity during exercise, suggesting they may lower blood pressure partly through the reduction of angiotensin vasoconstriction.
Bühler et al. (1974) studied Healthy volunteers (n=8). Beta-adrenergic blocking agents was evaluated on Plasma renin activity. Various beta-blocking agents significantly reduced plasma renin activity during upright exercise, independent of beta-1 or beta-2 receptor selectivity.
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