Why the study?
Do beta-adrenergic receptor blocking drugs reduce blood pressure via changes in plasma renin activity in hypertensive patients?
Population
Hypertensive patients
Design
Cohort
Follow-up
Chronic and acute (within 4 hours)
Authors
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Findings do not support plasma renin activity as mediator of beta-blocker BP reduction; leaves open alternative mechanisms for study.
Do beta-adrenergic receptor blocking drugs reduce blood pressure via changes in plasma renin activity in hypertensive patients?
The antihypertensive effect of beta-blockers like propranolol and pindolol does not appear to be mediated by changes in plasma renin activity.
Morgan et al. (1975) studied this question.
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