Why the study?
Does pindolol compared to propranolol affect the formation of active renin from its inactive precursor in primary hypertensives?
Population
18 primary hypertensives (12 male, 6 female, mean age 57.7 +/- 2.7)
Comparison
Pindolol vs Propranolol and placebo
Design
RCT, double-blind
Authors
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Pindolol may be selected to limit renin suppression or bradycardia at equivalent BP control; confirms ISA beta-blockers spare active renin formation.
Does pindolol compared to propranolol affect the formation of active renin from its inactive precursor in primary hypertensives?
Beta-blockers with intrinsic sympathomimetic activity, such as pindolol, have little net effect on the conversion of inactive to active renin compared to non-ISA beta-blockers like propranolol.
Ruddy et al. (1989) studied this question.
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