Key result
Systemic lupus erythematosus is linked to ~3% reduced peak systolic GLS compared to healthy controls.
Why the study?
Does 3D speckle tracking imaging detect early left ventricular systolic dysfunction in patients with systemic lupus erythematosus compared to healthy controls?
Population
34 patients with systemic lupus erythematosus (SLE) and 34 healthy subjects
Comparison
Three-dimensional speckle tracking… vs Healthy subjects
Design
Case-control
Authors
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May support GLS for subclinical LV dysfunction detection in SLE; leaves open prospective validation before clinical adoption.
Case-Control (n=68)
Does 3D speckle tracking imaging detect early left ventricular systolic dysfunction in patients with systemic lupus erythematosus compared to healthy controls?
Absolute Event Rate: -18.2% vs -21.4%
p-value: p=<0.01
Three-dimensional speckle tracking echocardiography can identify early subclinical left ventricular systolic dysfunction in SLE patients who otherwise have normal LV systolic function on standard 2D echocardiography.
Huang et al. (2014) conducted a case-control in Systemic lupus erythematosus (n=68). Systemic lupus erythematosus vs. Healthy subjects was evaluated on Peak systolic global longitudinal strain (GLS) (p=<0.01). Systemic lupus erythematosus was associated with significantly reduced peak systolic global longitudinal strain compared to healthy controls (-18.2% vs -21.4%, P<0.01).
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