Key result
SLE is linked to reduced GLS versus healthy controls, indicating early systolic dysfunction.
Why the study?
Cardiac dysfunction in systemic lupus erythematosus may be subclinical despite patients being at high risk for clinical heart failure, motivating evaluation of speckle tracking echocardiography for early detection.
Does speckle tracking echocardiography detect early subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus compared to healthy controls?
Case-Control (n=100)
Does speckle tracking echocardiography detect early subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus compared to healthy controls?
Absolute Event Rate: -18.95% vs -21.4%
p-value: p=<0.001
Speckle tracking echocardiography can detect subclinical left ventricular systolic dysfunction in SLE patients before LVEF declines.
Speckle tracking may identify subclinical LV dysfunction in SLE; hypothesis-generating and should not yet change practice.
Background: Cardiac dysfunction due to systemic lupus erythematosus (SLE) may be subclinical, but those patients are at high risk for developing clinical heart failure. Aim: The aim of this study is to assess the role of speckle tracking echocardiography (STE) in the early detection of systolic dysfunction in SLE patients. Patients and Methods: This was a case–control study. Participants were subdivided into two groups: Group 1 included 50 SLE patients and Group 2 included 50 healthy controls. Clinical evaluation, echocardiography, tissue Doppler, and STE were performed. Results: Global longitudinal strain (GLS) was significantly reduced in SLE group (−18.95 ± 2.02 vs. −21.4 ± 2.1, P < 0.001). However, there was no significant difference in left ventricular ejection fraction between both groups (P = 0.801). There was a significant positive correlation between the disease duration and age (r = 0.480, P < 0.001), pulmonary artery systolic pressure (PASP) (r = 0.628, P < 0.001), and GLS (%) (r = 0.417, P = 0.012). There was also a significant positive correlation between the disease activity index and GLS (%) (r = 0.7, P < 0.001) and PASP (r = 0.522, P < 0.001). Conclusion: SLE group had GLS % lower than the control group, and this was statistically significant, denoting early systolic dysfunction. Longer duration and high SLE activity index significantly affect GLS. GLS is an excellent noninvasive tool for early detection of subclinical left ventricular systolic dysfunction in SLE patients.
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Bastawisy et al. (2020) conducted a case-control in Systemic lupus erythematosus (SLE) (n=100). Systemic lupus erythematosus (SLE) vs. Healthy controls was evaluated on Global longitudinal strain (GLS) (p=<0.001). Systemic lupus erythematosus was associated with significantly reduced global longitudinal strain compared to healthy controls (-18.95 vs. -21.4, P<0.001), indicating early systolic dysfunction.
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