Key result
Combined exercise reduces carotid intima-media thickness by ~10% vs control in obese women with metabolic syndrome.
Why the study?
The study investigated the effects of 12 weeks of combined exercise on vascular function-related inflammation, carotid intima-media thickness, and fitness factors in obese middle-aged women with metabolic syndrome.
Does 12 weeks of combined exercise improve vascular function-related inflammation, carotid intima-media thickness, and physical fitness in obese middle-aged women with metabolic syndrome?
RCT (n=40)
Open-label
Randomized
No
Does 12 weeks of combined exercise improve vascular function-related inflammation, carotid intima-media thickness, and physical fitness in obese middle-aged women with metabolic syndrome?
Absolute Event Rate: 0.57% vs 0.63%
p-value: p=<0.05
A 12-week combined exercise program significantly improves body composition, blood pressure, inflammation, and carotid intima-media thickness in obese women with metabolic syndrome.
May support combined exercise for vascular markers in obese women with metabolic syndrome; hypothesis-generating, requiring RCTs before practice change.
Purpose: The purpose of this study was to investigate the effects of 12 weeks of combined exercise on vascular function-related inflammation, carotid intima-media thickness and fitness factors in obese middle-aged women with metabolic syndrome.M ethods: The subjects of this study were 40 middle-aged women in their 40s with metabolic syndrome but no specific disease.The exercise group performed aerobic exercise and resistance exercise five times a week for 12 weeks, and then measured body composition, blood pressure, vascular function-related inflammation factors, metabolic syndrome factors, carotid intima-media thickness, and physical factors.Results: The exercise group showed a significant (p＜ 0.05) reduction after exercise in all items related to body composition, systolic and diastolic blood pressure, and intima-media thickness of the right carotid and left carotid arteries.Exercise group showed a significant decrease (p＜ 0.05) after exercise in interleukin-6, tumor necrosis factor-α, leptin, and all items of glucose metabolism-related variables.The exercise group showed a significant (p＜0.05)increase after exercise physical efficiency index, grip strength, sit-ups, and sit & reach.After 12 weeks of exercise training, the reduction of intima-media thickness of the carotid artery was significantly (p＜ 0.05) correlated with the improvement of body weight, systolic and diastolic blood pressure, grip and sit & reach, blood HbA1c, and triglyceride concentration.Conclusion: In conclusion, metabolic syndrome improved the body composition, blood glucose metabolism and lipid variables after 12 weeks of combined exercise program for obese middle-aged women.Significant improvement in blood pressure and carotid endometrial thickness, which is a function-related indicator, was confirmed.
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Kijin Kim (2019) conducted an RCT in Metabolic syndrome and obesity (n=40). Combined exercise (aerobic and resistance) vs. No exercise program (Control) was evaluated on Left carotid intima-media thickness (mm) at 12 weeks (p=<0.05). A 12-week combined exercise program significantly reduced left carotid intima-media thickness, blood pressure, and inflammatory markers compared to control in obese women with metabolic syndrome.
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