Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (T) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology ( Hori et al., Pasare and Medzhitov).
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Powrie et al. (2003) studied this question.
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