Key result
KCNQ1 rs2283228 polymorphism is linked to ~22% lower T2DM risk in northwestern Chinese populations.
Why the study?
The correlation between KCNQ1 gene polymorphisms and the risk of T2DM remained controversial and needed evaluation in the population of northwestern China.
Are KCNQ1 gene polymorphisms associated with the risk of type 2 diabetes mellitus in the population of northwestern China?
Case-Control (n=1,011)
No
Are KCNQ1 gene polymorphisms associated with the risk of type 2 diabetes mellitus in the population of northwestern China?
Odds Ratio: 0.78 (95% CI 0.65–0.93)
p-value: p=0.007
KCNQ1 gene polymorphisms, particularly rs2237895 and rs2283228, are significantly associated with an increased risk of type 2 diabetes in the northwestern Chinese and broader East Asian populations.
KCNQ1 variants linked to T2DM risk in northwestern China; leaves open whether they improve risk prediction or prevention strategies.
Aims The purpose of this study was to explore the correlation between Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene polymorphisms and the risk of type 2 diabetes mellitus (T2DM) and its clinical indicators in the population of northwestern China, and conducted a meta-analysis on two polymorphic loci that have been studied frequently and controversial. Methods A case control study was conducted, involving 508 patients and 503 healthy individuals in the population of northwest China, and evaluated the associations using the χ2 test, Fisher's exact test, T test, and genetic model analyses. Results We discovered that rs2237895 rs2283228, rs163184, and rs163177 were associated with susceptibility to T2DM. Rs231362 rs231356, rs8181588 were related to the risk of T2DM after stratification. The results of meta-analysis also confirmed that rs2237895 and rs2283228 were strongly correlated with T2DM risk, especially in the East Asian population. Conclusions This study provides evidence for the correlation between KCNQ1 gene polymorphisms and T2DM in the population of northwestern China.
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Xu et al. (2019) conducted a case-control in Type 2 diabetes mellitus (n=1,011). KCNQ1 gene polymorphisms (rs2283228) vs. Major allele carriers / Healthy controls was evaluated on Susceptibility to Type 2 Diabetes Mellitus (OR 0.78, 95% CI 0.65-0.93, p=0.007). The KCNQ1 rs2283228 polymorphism was associated with a significantly reduced risk of type 2 diabetes (OR 0.78) in the northwestern Chinese population.
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