Key result
KCNQ1 rs2237892 polymorphism linked to ~35% higher risk of type 2 diabetes in Asians.
Why the study?
The association between KCNQ1 rs2237892 C→T gene polymorphism and T2DM susceptibility in the Asian population showed conflicting results in various studies.
Is the KCNQ1 rs2237892 C→T gene polymorphism associated with increased risk of type 2 diabetes mellitus in the Asian population?
Meta-Analysis (n=15,736)
Yes
Is the KCNQ1 rs2237892 C→T gene polymorphism associated with increased risk of type 2 diabetes mellitus in the Asian population?
Odds Ratio: 1.35 (95% CI 1.24–1.48)
p-value: p=< 0.00001
The C allele of the KCNQ1 rs2237892 C→T gene polymorphism is significantly associated with increased susceptibility to type 2 diabetes mellitus in most Asian populations.
Confirms KCNQ1 rs2237892 association with T2DM in Asians; leaves open clinical utility and causal validation.
The KCNQ1 rs2237892 C→T gene polymorphism is reportedly associated with T2DM susceptibility, but various studies show conflicting results. To explore this association in the Asian population, a meta-analysis of 15,736 patients from 10 individual studies was performed. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were evaluated using random-effect or fixed-effect models. A significant relationship between the KCNQ1 rs2237892 C→T gene polymorphism and T2DM was observed in the Asian population under the allelic (OR, 1.350; 95% CI, 1.240-1.480; P < 0.00001), recessive (OR: 0.650; 95% CI: 0.570-0.730; P < 0.00001), dominant (OR: 1.450; 95% CI: 1.286-1.634; P < 0.00001), and additive (OR: 1.346; 95% CI: 1.275-1.422; P < 0.00001) genetic models. In the subgroup analysis by race, a significant association was found in Chinese, Korean and Malaysia population, but not in Indian population. KCNQ1 rs2237892 C→T gene polymorphism was found to be significantly associated with increased T2DM risk in the Asian population, except Indian population. The C allele of the KCNQ1 rs2237892 C→T gene polymorphism may confer susceptibility to T2DM.
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Li et al. (2013) conducted a meta-analysis in Type 2 diabetes mellitus (n=15,736). KCNQ1 rs2237892 C→T gene polymorphism vs. Reference allele/genotype was evaluated on Type 2 diabetes mellitus (OR 1.350, 95% CI 1.240-1.480, p=< 0.00001). The KCNQ1 rs2237892 C→T gene polymorphism was significantly associated with increased susceptibility to type 2 diabetes mellitus in Asian populations (allelic OR 1.350; 95% CI 1.240-1.480; P<0.00001).
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