Key result
Antiarrhythmic therapy for benign arrhythmias is linked to life-threatening TdP or VF in four patients.
Why the study?
Does antiarrhythmic therapy for low-malignant arrhythmias carry a risk of proarrhythmia such as torsade de pointes or ventricular fibrillation?
Case Report (n=4)
Does antiarrhythmic therapy for low-malignant arrhythmias carry a risk of proarrhythmia such as torsade de pointes or ventricular fibrillation?
Antiarrhythmic therapy for benign arrhythmias carries a significant risk of lethal proarrhythmias like torsade de pointes, especially when agents are used in combination.
No takes yet. Share an insight, caveat, or question.
May warrant caution with antiarrhythmics even for benign arrhythmias; leaves open generalizability beyond this case series.
Faber et al. (1994) conducted a case report in supraventricular or benign ventricular arrhythmias (n=4). Antiarrhythmic therapy was evaluated on ventricular fibrillation or torsade de pointes. Antiarrhythmic therapy for benign or supraventricular arrhythmias was associated with the occurrence of life-threatening torsade de pointes or ventricular fibrillation in four patients.
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