Key result
TIMI and GRACE scores predict ACS mortality but require caution across different demographics.
While TIMI and GRACE risk scores are extensively used for ACS prognosis, their generalizability requires caution due to ongoing disparities in aggressive treatment across gender, age, and ethnicity.
May refine ACS risk stratification by integrating clinical judgment with TIMI/GRACE scores; leaves open prospective validation of combined models.
Acute coronary syndrome (ACS) is associated with both short- and long-term unfavorable prognosis. Therefore, medical societies developed risk scores for predicting mortality and assessing decision-making regarding early aggressive treatment in patients presenting an ACS. The Thrombolysis In Myocardial Infarction and the Global Registry of Acute Coronary Events risk scores are the most extensively investigated scores for ACS. Clinical judgment is also important. Significant differences in aggressive treatment of ACS still exist with respect to gender, age, and ethnicity. The reasons for these discrepancies need to be further elucidated in future studies. Therefore, generalizability of stratifications and risk scores in certain populations should be performed with caution.
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Kolovou et al. (2016) conducted a review in Acute coronary syndrome. Risk scores (TIMI and GRACE) was evaluated. Risk scores such as TIMI and GRACE are extensively used for predicting mortality in acute coronary syndrome, though their generalizability across different demographics requires caution.
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