Key result
Oral vitamin K1 may safely lower INR as a less painful alternative to parenteral therapy.
Why the study?
Does oral vitamin K1 reduce INR in patients receiving warfarin therapy who are at risk of bleeding?
Case Report (n=6)
Does oral vitamin K1 reduce INR in patients receiving warfarin therapy who are at risk of bleeding?
Oral vitamin K1 is a safe, less painful, and cost-effective alternative to parenteral administration for reversing warfarin-induced elevated INR.
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Does not support practice change in warfarin reversal; single case report leaves open need for randomized trials.
Harrell et al. (1995) conducted a case report in Increased INR and at risk of bleeding while on warfarin therapy (n=6). Oral vitamin K1 (phytonadione) vs. Parenteral vitamin K1 (historical/theoretical) was evaluated on Reduction of international normalized ratio (INR). Oral vitamin K1 therapy may be a safer, less painful, and more cost-effective alternative to parenteral administration for reducing INR in warfarin-treated patients at risk of bleeding.
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