Key result
Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10.
Why the study?
Does a single 2.5 mg dose of oral vitamin K safely manage INR values > 10 without causing excessive thromboembolism or major bleeding in warfarin-treated patients?
Population
107 warfarin-treated patients with INR values of more than 10 who are not actively bleeding
Design
Cohort
Follow-up
90 days
Authors
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May support oral vitamin K for INR >10 in non-bleeding warfarin patients; leaves open randomized confirmation of thromboembolism risk.
Does a single 2.5 mg dose of oral vitamin K safely manage INR values > 10 without causing excessive thromboembolism or major bleeding in warfarin-treated patients?
A single 2.5 mg dose of oral vitamin K is a reasonable and safe treatment for warfarin-treated patients with INR > 10 who are not actively bleeding, associated with a low rate of major bleeding.
Garcia et al. (2010) studied International normalised ratio (INR) values in excess of 10. Oral vitamin K was evaluated. Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10.
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