Why the study?
Does low-dose oral vitamin K therapy reduce elevated INR in asymptomatic patients?
Population
Asymptomatic patients with elevated international normalized ratios, specifically INR values between 4.5 and…
Comparison
Low-dose oral vitamin K therapy vs Subcutaneous vitamin K injection or intravenous…
Design
Review
Follow-up
24 hours
Authors
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May support preferring oral over subcutaneous vitamin K for elevated INR; leaves open need for randomized confirmation before practice change.
Does low-dose oral vitamin K therapy reduce elevated INR in asymptomatic patients?
Low-dose oral vitamin K (1.0 mg) is an effective and safe strategy for promptly reducing elevated INR (4.5-10) in asymptomatic patients, outperforming subcutaneous administration.
Sarah Wilson (2004) studied this question.
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