Key result
Oral administration of 2.5 mg vitamin K1 returned 77% of patients with an initial INR of 8.0-11.9 to a safe INR of 2.0-4.9 within 1 day.
Why the study?
Does orally administered phytomenadione reduce INR to a safe level in patients with asymptomatic over-anticoagulation on warfarin?
Population
223 patients with asymptomatic over-anticoagulation on warfarin (INR > 8.0)
Design
Cohort
Follow-up
14 days
Authors
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Supports low-dose oral vitamin K for asymptomatic high-INR warfarin reversal; confirms RCT efficacy for outpatient management.
Cohort (n=223)
Does orally administered phytomenadione reduce INR to a safe level in patients with asymptomatic over-anticoagulation on warfarin?
Baker et al. (2006) conducted a cohort in Asymptomatic over-anticoagulation with warfarin (n=223). Oral phytomenadione (vitamin K1) was evaluated on INR between 2.0 and 4.9 on day 1 (approximately 14 h). Oral administration of 2.5 mg vitamin K1 returned 77% of patients with an initial INR of 8.0-11.9 to a safe INR of 2.0-4.9 within 1 day.
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