Key result
A form of ATP uncomplexed with divalent cations is the preferential agonist of both the nucleotide/P2u and the P2y receptors expressed on bovine aortic endothelial cells.
Population
Bovine aortic endothelial cells
Comparison
ATP, UTP, and 2MeSATP under varying… vs Different buffer conditions
Design
Preclinical
Authors
Loading...
Hypothesis-generating for ATP4- at endothelial P2 receptors; leaves open translation to human vascular physiology or therapy.
A form of ATP uncomplexed with divalent cations (ATP4-) is the preferential agonist for P2y and nucleotide/P2u receptors on bovine aortic endothelial cells.
Motte et al. (1993) studied this question. ATP uncomplexed with divalent cations vs. ATP complexed with divalent cations (Mg2+) was evaluated on inositol phosphate accumulation. A form of ATP uncomplexed with divalent cations is the preferential agonist of both the nucleotide/P2u and the P2y receptors expressed on bovine aortic endothelial cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: