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April 27, 2023International Journal of Basic & Clinical PharmacologyOpen Access

Modified pectoral nerve block cuts 24-hour postoperative morphine use ~39% versus erector spinae block.

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Why the study?

Failure to provide effective pain control after breast surgery impairs recovery, prompting comparison of modified pectoral nerve block versus erector spinae plane block for post-operative pain relief.

Does modified pectoral nerve block improve postoperative pain control compared to erector spinae block in female patients undergoing modified radical mastectomy?

Population

80 female patients aged 25-65 years undergoing modified radical mastectomy

Comparison

Modified pectoral nerve block vs erector spinae block

Design

Prospective randomized comparative study

Key result

Modified pectoral nerve block significantly reduced 24-hour postoperative morphine consumption (4.6 mg vs 7.5 mg) and prolonged the duration of analgesia compared to erector spinae block in patients undergoing modified radical mastectomy.

Authors

PSPriadharshini ShanmugamHDHemalatha DunnaPSPaleti Sophia

Discussion

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Member takes

Overview

Supports preferring modified pectoral nerve block for post-mastectomy analgesia; extends RCT comparisons of regional techniques in breast surgery.

Study Design

Type

RCT (n=80)

Randomization

Randomly allocated

Multicenter

No

Structured PICO

Does modified pectoral nerve block improve postoperative pain control compared to erector spinae block in female patients undergoing modified radical mastectomy?

P
Population
80 female patients aged 25-65 years with ASA class I or II undergoing elective unilateral modified radical mastectomy, followed for 24 hours postoperatively.
I
Intervention
Modified pectoral nerve block (PEC 2) with 0.2% ropivacaine 25 ml.
C
Comparator
Erector spinae plane block (ESP) with 0.2% ropivacaine 25 ml.
O
Outcome
Postoperative pain relief (assessed by opioid consumption, duration of analgesia, and postoperative pain score).patient reported

Main Result

Absolute Event Rate: 4.6% vs 7.5%

p-value: p=0.0007

Modified pectoral nerve block provides superior postoperative analgesia and reduces opioid consumption compared to erector spinae block in patients undergoing modified radical mastectomy.

Cite This Study

Shanmugam et al. (2023) conducted an RCT in Breast cancer undergoing modified radical mastectomy (n=80). Modified pectoral nerve block vs. Erector spinae block was evaluated on Total morphine consumed in 24 hours (mg) (p=0.0007). Modified pectoral nerve block significantly reduced 24-hour postoperative morphine consumption (4.6 mg vs 7.5 mg) and prolonged the duration of analgesia compared to erector spinae block in patients undergoing modified radical mastectomy.

synapsesocial.com/papers/6aa6d7a4041e43fea73a85b7https://doi.org/10.18203/2319-2003.ijbcp20231128
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMPARISON OF POSTOPERATIVE ANALGESIC EFFECT OF ULTRASOUND GUIDED PECTORAL VS ERECTOR SPINAE BLOCK IN PATIENTS UNDERGOING MODIFIED RADICAL MASTECTOMY2024
  2. 2Comparative Study for Efficacy of Ultrasound Guided Pectoral Nerve Block versus Erector Spinae Plane Block for Post Operative Analgesia in Modified Radical Mastectomy2025
  3. 3Comparative Study between Pectoral Nerve Block Type-II (PECS II) and Serratus Anterior Plane Block (SAPB) in Postoperative Analgesic Efficacy in Modified Radical Mastectomy2024 · 1 citations
  4. 4Comparative study between Ultrasound guided Pectoral nerves block and Thoracic epidural as analgesia in breast surgeries2018 · 4 citations
  5. 5Pectoral Nerves Blocks for Post-Operative Analgesia after BreastCancer Surgery2021 · 2 citations