Key result
ODATE-1 mumps strain proves genetically unrelated to Urabe and Miyahara strains despite identical RFLP profiles.
Population
Mumps virus wild-type strain (ODATE-1 strain) associated with a high incidence of aseptic meningitis
Comparison
cDNA cloning and sequence analysis vs Urabe vaccine strain and Miyahara strain
Design
Preclinical
Authors
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Challenges RFLP reliability for mumps strain typing; sequence analysis leaves open ODATE-1 origins and vaccine surveillance needs.
Sequence analysis revealed that the ODATE-1 mumps strain, despite having an identical RFLP profile to the Urabe vaccine strain, is genetically distinct.
Saito et al. (1998) studied Aseptic meningitis associated with mumps virus. Genomic RNA sequence analysis of ODATE-1 strain vs. Urabe strain and Miyahara strain was evaluated on Nucleotide and amino acid sequence comparison. The ODATE-1 mumps virus strain, despite having an identical RFLP profile to the Urabe vaccine strain, was found to be unrelated to the Urabe and Miyahara strains based on sequence comparison.
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