Population
32 mumps patients aged 0-45 years who visited a tertiary care hospital in Eastern India
Design
Other
Key result
Molecular analysis of 32 mumps virus isolates from Odisha revealed all belonged to genotype C and carried a consistent Y44S substitution in the SH protein, potentially altering its flexibility.
Authors
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Y44S substitution in SH protein of genotype C strains may alter structure and interactions; leaves open its contribution to transmission or vaccine escape.
Observational (n=32)
No
The identification of a consistent Y44S mutation in the SH protein of genotype C mumps virus strains in India suggests a potential mechanism for altered viral replication or immune evasion.
Mamidi et al. (2025) conducted an observational in Mumps (n=32). Circulating mumps virus strains was evaluated on Viral genotype and SH gene mutations. Molecular analysis of 32 mumps virus isolates from Odisha revealed all belonged to genotype C and carried a consistent Y44S substitution in the SH protein, potentially altering its flexibility.
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