Key result
Ovariectomy induced hypertrophy and inflammation in perivascular adipose tissue and increased MMP-9 expression, leading to the degradation of arterial elastin and collagen fibers.
Why the study?
Although perivascular adipose tissue (PVAT) is suggested to be deeply involved in the increased risk of vascular disease development after menopause, the effect of menopause on PVAT integrity remains unknown.
Does ovariectomy cause degeneration of perivascular adipose tissue and arterial fibers in rats?
Does ovariectomy cause degeneration of perivascular adipose tissue and arterial fibers in rats?
p-value: p=<0.05
Ovariectomy induces perivascular adipose tissue dysfunction and arterial fiber degradation in rats, providing a potential mechanism for increased vascular risk post-menopause.
Does not support changes in post-menopausal care; leaves open whether perivascular adipose tissue changes mediate human arterial risk.
Women are more resistant than men to the development of vascular diseases. However, menopause is a factor leading to deterioration of female vascular integrity, and it is reported that the risk of vascular diseases such as atherosclerosis and abdominal aortic aneurysm is increased in postmenopausal women. Although it is suggested that perivascular adipose tissue (PVAT) is deeply involved in the increased risk of vascular disease development, the effect of menopause on PVAT integrity is unknown. In this study, we aimed to elucidate the effect of menopause on PVAT in ovariectomized (OVX) rats. PVAT was divided into 4 regions based on characteristics. Hypertrophy and increased inflammation of adipocytes in the PVAT were observed in the OVX group, but the effects of OVX were different for each region. OVX induced matrix metalloproteinase (MMP) -9 which degrade extracellular matrix such as elastin and collagen fibers in PVAT. Degeneration of the arterial fibers of the thoracic and abdominal aorta were observed in the OVX group. These results indicate that OVX can cause dysfunction of PVAT which can cause degradation of arterial fibers. Appropriate management of PVAT may play an important role in the prevention and treatment of diseases originating from ovarian hypofunction.
No takes yet. Share an insight, caveat, or question.
Nakamura et al. (2021) studied Vascular disease risk (Perivascular adipose tissue degeneration) (n=13). Ovariectomy vs. Sham treatment was evaluated on Degeneration of perivascular adipose tissue (adipocyte hypertrophy, inflammation, and arterial fiber degradation) (p=<0.05). Ovariectomy induced hypertrophy and inflammation in perivascular adipose tissue and increased MMP-9 expression, leading to the degradation of arterial elastin and collagen fibers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: