The alcoholic extract of Andrographis paniculata exhibited significant antidiarrhoeal activity against E. coli enterotoxins in animal models. The activity was further located in n-butanol fraction, which led to the isolation of four diterpenes, andrographolide (7), neoandrographolide (2), deoxyan-drographolide (3), and andrographiside (4). Among the four diterpenes, andrographolide and neoandrographolide showed similar activity to loperamide against E. coli LT and LT/ST enterotoxins. Andrographolide was found to be superior against ST enterotoxin, the most common cause of epidemics of neonatal diarrhoea.
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Gupta et al. (1990) studied this question.
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