What does this research mean for the field?

Concentration polarization elevates luminal surface LDL concentrations by 5% to 14% above bulk levels, with surface concentrations varying inversely with wall shear rate and linearly with filtration rate. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1998Annals of the New York Academy of Sciences

Concentration Polarization of Low Density Lipoproteins (LDL) in the Arterial Systema

Q: What is the clinical evidence from this study?

Study design: Other. Population: Atherosclerosis. Intervention: Pulsatile flow conditions vs. Steady-state flow conditions. Primary outcome: Luminal surface LDL concentration.

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Key result

Luminal surface LDL concentration runs ~5-14% higher than bulk concentration, varying inversely with shear rate.

Population

Numerical model of the arterial system simulating blood flow and LDL transport

Comparison

Pulsatile flow conditions vs Steady-state flow conditions

Design

Preclinical

Authors

NFNasser FatouraeeStructural Heart Disease XDXiaoyan DengChinese Academy of Tropical Agricultural Sciences ACAlain De ChamplainQueen's University

Discussion

Member takes

Implication

May help explain flow-dependent atherosclerosis localization; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

Numerical model of the arterial system simulating blood flow and LDL transport

Exposure

Pulsatile flow conditions

Comparator

Steady-state flow conditions

Outcome

Luminal surface LDL concentrationsurrogate

Numerical modeling suggests that concentration polarization of LDL occurs at the arterial wall, which is flow-dependent and may contribute to the localization of atherosclerosis.

Cite This Study

Fatouraee et al. (1998) studied Atherosclerosis. Pulsatile flow conditions vs. Steady-state flow conditions was evaluated on Luminal surface LDL concentration. Numerical analysis of LDL transport demonstrated that the time-average luminal surface LDL concentration is 5 to 14% greater than the bulk concentration, varying inversely with wall shear rate.

synapsesocial.com/papers/6aa6ecaf2e0c4dc4f87f499e https://doi.org/10.1111/j.1749-6632.1998.tb10148.x

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Concentration Polarization of Low Density Lipoproteins (LDL) in the Arterial Systema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Concentration Polarization of Low Density Lipoproteins (LDL) in the Arterial Systema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider