Key result
Kv2.1 potassium channels directly induce stable endoplasmic reticulum-plasma-membrane junctions in mammalian cells.
Kv2.1 channels function as structural hubs to induce ER-plasma-membrane junctions, representing a novel macromolecular complex sensitive to excitotoxic insult.
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May link Kv2.1 junctions to excitotoxic injury in excitable cells; leaves open relevance to human cardiovascular or neurological disease.
Fox et al. (2015) studied this question. Kv2.1 potassium channels was evaluated on Formation of ER-plasma-membrane junctions. Kv2.1 potassium channels play a direct structural role in inducing stable endoplasmic reticulum-plasma-membrane junctions in mammalian cells.
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