Key result
Depressive symptoms were associated with a 1.50-fold increased odds of elevated fasting plasma glucose in older Chinese adults, and a decreased odds of elevated systolic blood pressure specifically in men (OR 0.59).
Why the study?
Few studies have examined associations between depressive symptoms and metabolic syndrome among older Chinese adults, despite a high prevalence of depressive symptoms in this population.
Are depressive symptoms associated with metabolic syndrome and its components in older Chinese adults?
Cross-Sectional (n=4,579)
No
Are depressive symptoms associated with metabolic syndrome and its components in older Chinese adults?
Odds Ratio: 1.5 (95% CI 1–2.2)
p-value: p=0.05
In older Chinese adults, depressive symptoms are associated with elevated fasting glucose and diabetes, but paradoxically associated with lower systolic blood pressure in men.
May warrant depression screening in older diabetic patients; leaves open causal links to metabolic syndrome components pending longitudinal studies.
BACKGROUND: Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults. METHODS: Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria. RESULTS: In all participants, depressive symptoms were related to elevated fasting plasma glucose (≥ 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00-2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01-2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (≥ 130 mm Hg) (OR = 0.59, 95% CI [0.4-0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. CONCLUSIONS: In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.
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Liu et al. (2020) conducted a cross-sectional in Depressive symptoms and metabolic syndrome (n=4,579). Depressive symptoms vs. No depressive symptoms was evaluated on Elevated fasting plasma glucose (≥ 7.0 mmol/L) (OR 1.50, 95% CI 1.00-2.20, p=0.05). Depressive symptoms were associated with a 1.50-fold increased odds of elevated fasting plasma glucose in older Chinese adults, and a decreased odds of elevated systolic blood pressure specifically in men (OR 0.59).
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