Key result
Baseline metabolic syndrome was associated with a significantly higher incidence of major depressive disorder in women (OR 1.82) but not in men over a median follow-up of 4.66 years.
Why the study?
The study aimed to assess the cumulative incidence of major depressive disorder among rural Chinese residents and determine whether metabolic syndrome was associated with it.
Is metabolic syndrome associated with an increased incidence of major depressive disorder in rural Chinese residents?
Cohort (n=2,796)
Yes
Is metabolic syndrome associated with an increased incidence of major depressive disorder in rural Chinese residents?
Odds Ratio: 1.82 (95% CI 1.01–3.27)
Absolute Event Rate: 7.3% vs 3.8%
p-value: p=0.045
Metabolic syndrome is associated with an increased risk of developing major depressive disorder in women, but not men, in rural China.
MetS associated with incident MDD in rural Chinese women but not men; leaves open causality and targeted prevention.
BACKGROUND: The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis. METHOD: Data of 11,675 residents (46.3% men) was used for cross-sectional analysis. The residents were followed up with median 4.66 years. MDD was diagnosed using the Patient Health Questionnaire-9 (PHQ-9). The data of 2796 individuals without any depressive symptoms was used for prospective analysis. RESULT: With median of 4.66 years follow-up, the cumulative incidence of MDD among rural residents was 3.9%. Women had significantly higher cumulative incidence of MDD than men (5.3% for women and 2.9% for men, P < 0.01). The incidence of MDD was significantly higher among women with MetS (7.3% vs. 3.8%, P < 0.001), hypertriglyceridemia (7.0% vs. 4.5%, P < 0.001) or elevated blood pressure (6.4% vs. 3.4%, P < 0.001) at baseline compared with those without them. There was no incidence difference of MDD among men with or without baseline metabolic disorders. In prospective study, after adjusting possible confounders, baseline MetS was associated with higher incidence of MDD (OR: 1.82, 95%CI: 1.01, 3.27, P = 0.045) in women but not men (OR: 1.84, 95%CI: 0.88, 3.83, P = 0.104). CONCLUSION: Cumulative incidence of MDD in rural China was higher among women than among men. Baseline MetS was associated with higher cumulative incidence of MDD in women but not men. More concern should be put on women with MetS in case of onset depressive symptom in future.
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Yu et al. (2020) conducted a cohort in Major depressive disorder (n=2,796). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Incidence of major depressive disorder (MDD) in women (OR 1.82, 95% CI 1.01, 3.27, p=0.045). Baseline metabolic syndrome was associated with a significantly higher incidence of major depressive disorder in women (OR 1.82) but not in men over a median follow-up of 4.66 years.
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