Key result
Mutations in calcium-transport genes ATP2A2, RYR2, and CASQ2 contribute to contractile dysfunction and heart failure.
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Design
Review
This review highlights the genetic contributions of calcium-transporting system proteins to the development of heart failure.
This review contains data reflecting the role of polymorphisms and mutations of the genes of proteins Ca 2+ -ATPase 2a, ryanodine receptors, and calsequestrin of the Ca 2+ -transporting system of the sarcoplasmic reticulum of cardiomyocytes in the formation of contractile myocardial dysfunction.
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Rebrova et al. (2018) studied this question. Polymorphisms and mutations in the ATP2A2, RYR2, and CASQ2 genes of the cardiomyocyte calcium-transporting system contribute to contractile myocardial dysfunction and heart failure.
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