Increased ryanodine receptor type 2 phosphorylation has disputed functional effects, and its role in the pathogenesis of heart failure and arrhythmias remains controversial.
Cardiac ryanodine receptor type 2 plays a key role in excitation-contraction coupling. The ryanodine receptor type 2 channel protein is modulated by various post-translational modifications, including phosphorylation by protein kinase A and Ca(2+)/calmodulin protein kinase II. Despite extensive research in this area, the functional effects of ryanodine receptor type 2 phosphorylation remain disputed. In particular, the potential involvement of increased ryanodine receptor type 2 phosphorylation in the pathogenesis of heart failure and arrhythmias remains a controversial area, which is discussed in this review article.
Dobrev et al. (Thu,) conducted a review in Heart failure and arrhythmias. Ryanodine receptor type 2 (RyR2) phosphorylation was evaluated. Increased ryanodine receptor type 2 phosphorylation has disputed functional effects, and its role in the pathogenesis of heart failure and arrhythmias remains controversial.